Respiratory muscles and weaning failure

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Respiratory muscles and weaning failure.

Weaning failure is, unfortunately, a rather common phenomenon for mechanically-ventilated patients (especially those with chronic obstructive pulmonary disease (COPD)), and the respiratory muscles play a pivotal role in its development. Weaning fails whenever an imbalance exists between the ventilatory needs and the neurocardiorespiratory capacity. This can happen if there is an increase in the...

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Role of the respiratory muscles in acute respiratory failure of COPD: lessons from weaning failure.

It is problematic to withhold therapy in a patient with chronic obstructive pulmonary disease (COPD) who presents with acute respiratory failure so that detailed physiological measurements can be obtained. Accordingly, most information on respiratory muscle activity in patients experiencing acute respiratory failure has been acquired by studying patients who fail a trial of weaning after a peri...

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The Respiratory Muscles in Chronic Obstructive Pulmonary Disease Role of the respiratory muscles in acute respiratory failure of COPD: lessons from weaning failure

Tobin MJ, Laghi F, Brochard L. Role of the respiratory muscles in acute respiratory failure of COPD: lessons from weaning failure. J Appl Physiol 107: 962–970, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.00165.2009.—It is problematic to withhold therapy in a patient with chronic obstructive pulmonary disease (COPD) who presents with acute respiratory failure so that detailed ...

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Bench-to-bedside review: Weaning failure – should we rest the respiratory muscles with controlled mechanical ventilation?

The use of controlled mechanical ventilation (CMV) in patients who experience weaning failure after a spontaneous breathing trial or after extubation is a strategy based on the premise that respiratory muscle fatigue (requiring rest to recover) is the cause of weaning failure. Recent evidence, however, does not support the existence of low frequency fatigue (the type of fatigue that is long-las...

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Peripheral and respiratory muscles in chronic heart failure.

It is well-established that in patients with congestive heart failure (CHF), exercise is limited by fatigue and shortness of breath. The poor correlation between the fatigue and indices of central haemodynamic function might indicate that peripheral muscle alterations contribute to impaired exercise capacity. Intrinsic abnormalities of the skeletal muscles have been suggested as a possible expl...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 1996

ISSN: 0000-0000,0903-1936

DOI: 10.1183/09031936.96.09112383